My buddy and I started out in a little town called Azalia. It is south of Columbus. There is a public access site off 800 S, which connects Highway 11 and 31. Can't miss it.
The trip begins slow, but you are introduced to a few rapids a few miles in. I'm not sure about normally, but 2012 was a terrible drought, which made all rivers really slow. We never had to get out, though and push our boats across rocks or anything though.
There is plenty wildlife to look at. We noticed on one trip an eagle, and plenty of wild birds. Have seen several small snakes but nothing harmful. Downed trees was not an issue except on about mile 2 or 3. You will come to a fork in the river where the main section of the river is blocked, and you must go around. This part can be dangerous as my friend and I tried to go this way and here there were rapids pushing us towards the blocked wall. Luckily we were strong enough to go up river slightly in the rapids and go the other way around but if you knew ahead of time (paying attention!) you will know which way to go (will be obvious).
You will know when you are about halfway when you go under interstate 65 bridge. You will be 2/3's the way there when you get to the 31 bridge and will have about a mile left after the railroad track bridge. There are many houses on the route. We saw cows under interstate 65 bridge. They were very stubborn and would not get out of the river and we were just within feet from them. Funny experience!
We never saw anyone else kayaking/canoeing and you will work up a sweat paddling this section of the East Fork River, but we went nonstop. Bring plenty of water and maybe a snack. Enjoy the trip!